Schmidt, T; Lorenz, N; Raker, VK; Schmidgen, MI; Mahnke, K; Enk, A; Roth, J; Steinbrink K.
Letter to the editor (journal) | Peer reviewedLow zone tolerance (LZT) is regarded as a physiological mechanism to regulate and to circumvent allergies to contact allergens. It is induced by epicutaneous applications of low doses of haptens resulting in the generation of IL-10-producing CD4+CD25+Foxp3+ regulatory T cells and CD8+ suppressor T cells (Luckey et al., 2011, Luckey et al., 2012). LZT induction prevents the development of the Tc1-mediated contact hypersensitivity (CHS), which mimics the allergic contact dermatitis in humans. However, the role of the innate immune system during the early phase of LZT is still elusive.
Raker, Verena | Clinic for Dermatology |
Roth, Johannes | Center of Child and Adolescent Medicine |
Steinbrink, Kerstin | Clinic for Dermatology |