Allergen-Specific Low Zone Tolerance Is Independent of MRP8/14-, TLR4-, TLR7-, and TLR9-Mediated Immune Processes

Schmidt, T; Lorenz, N; Raker, VK; Schmidgen, MI; Mahnke, K; Enk, A; Roth, J; Steinbrink K.

Letter to the editor (journal) | Peer reviewed

Abstract

Low zone tolerance (LZT) is regarded as a physiological mechanism to regulate and to circumvent allergies to contact allergens. It is induced by epicutaneous applications of low doses of haptens resulting in the generation of IL-10-producing CD4+CD25+Foxp3+ regulatory T cells and CD8+ suppressor T cells (Luckey et al., 2011, Luckey et al., 2012). LZT induction prevents the development of the Tc1-mediated contact hypersensitivity (CHS), which mimics the allergic contact dermatitis in humans. However, the role of the innate immune system during the early phase of LZT is still elusive.

Details about the publication

JournalJournal of Investigative Dermatology
Volume138
Issue2
Page range452-455
StatusPublished
Release year2018
DOI10.1016/j.jid.2017.09.020
Link to the full texthttps://www.sciencedirect.com/science/article/pii/S0022202X17329743?via=ihub
Keywordscontact hypersensitivity; Low zone tolerance; myeloid related protein; toll-like receptor

Authors from the University of Münster

Raker, Verena
Clinic for Dermatology
Roth, Johannes
Center of Child and Adolescent Medicine
Steinbrink, Kerstin
Clinic for Dermatology