An AI-assisted cryo-EM pipeline for structural studies of cellular extracts

Bourque C; Klink BU; Gatsogiannis C

Abstract

Proteins, the building blocks of life, often form large assemblies to perform their function but are traditionally studied separately in structural biology. In this issue of Structure, Skalidis et~al. (2022) present a workflow to identify members of intact protein communities and solve their structures de novo to near-atomic resolution.