Resolving the cognitive clinico-radiological paradox - Microstructural degeneration of fronto-striatal-thalamic loops in early active multiple sclerosis.
Johnen A, Schiffler P, Landmeyer NC, Tenberge JG, Riepl E, Wiendl H, Krämer J, Meuth SG
Research article (journal) | Peer reviewedAbstract
Microstructural degeneration within specific fronto-striatal-thalamic WM networks, previously characterized as crucial for task-monitoring, better accounts for speed-dependent CI in patients with early active RRMS than global or regional brain volumes. Our findings may advance our understanding of the neural substrates underlying CI characteristic for early RRMS.
Details about the publication
Journal: Cortex
Volume: 121
Page range: 239-252
Status: Published
Release year: 2019 (30/01/2020)
Language in which the publication is written: English
Keywords: Adult; Attention; Cognitive Dysfunction; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; Executive Function; Female; Gray Matter; Humans; Male; Middle Aged; Multiple Sclerosis; Thalamus; White Matter
Authors from the University of Münster
| Krämer, Julia | Department for Neurology |
| Landmeyer, Nils Christian | Department for Neurology |
| Wiendl, Heinz Siegfried | Department for Neurology |