Severe disease exacerbation after mRNA COVID-19 vaccination unmasks suspected multiple sclerosis as neuromyelitis optica spectrum disorder: a case report.
Lohmann L, Glaser F, Möddel G, Lünemann JD, Wiendl H, Klotz L
Research article (journal) | Peer reviewedAbstract
Pathogenic mechanisms of post-vaccination occurrence of NMOSD are still unknown. However, cases like this should make aware of rare neurological disorders manifesting after vaccination and potentially contribute to improvement of management of vaccinating patients with inflammatory CNS disorders in the future. So far two cases of AQP4-antibody positive NMOSD have been reported in association with viral vector COVID-19 vaccines. To our knowledge, we report the first case of AQP4-antibody positive NMOSD after immunization with an mRNA COVID-19-vaccine.
Details about the publication
Journal: BMC Neurology
Volume: 22
Issue: 1
Page range: 185-185
Status: Published
Release year: 2022 (18/05/2022)
Language in which the publication is written: English
Keywords: Aged; Aquaporin 4; Autoantibodies; BNT162 Vaccine; COVID-19; COVID-19 Vaccines; Disease Progression; Female; Humans; Multiple Sclerosis; Myelitis, Transverse; Neuromyelitis Optica; Pandemics; RNA, Messenger; Vaccination
Authors from the University of Münster
| Glaser, Felix Martin | Department for Neurology |
| Klotz, Luisa Hildegard | Department for Neurology |
| Lünemann, Jan | Department for Neurology |
| Revie, Lisa Maria | Department for Neurology |
| Wiendl, Heinz Siegfried | Department for Neurology |