Increased Intrathecal B and Plasma Cells in Patients With Anti-IgLON5 Disease: A Case Series.

Strippel C, Heidbreder A, Schulte-Mecklenbeck A, Korn L, Warnecke T, Melzer N, Wiendl H, Pawlowski M, Gross CC, Kovac S

Research article (journal) | Peer reviewed

Abstract

Our findings indicate the importance of inflammatory mechanisms, in particular in early and acute anti-IgLON5 cases, which may support the use of immune-suppressive treatments in these cases. The main limitation of the study is the small number of cases due to the rarity of the disease.

Details about the publication

JournalNeurology: Neuroimmunology and NeuroInflammation (Neurol Neuroimmunol Neuroinflamm)
Volume9
Issue2
StatusPublished
Release year2022 (01/05/2022)
Language in which the publication is writtenEnglish
DOI10.1212/NXI.0000000000001137
KeywordsAged; Aged, 80 and over; Autoantibodies; Autoimmune Diseases of the Nervous System; B-Lymphocytes; Cell Adhesion Molecules, Neuronal; Female; Humans; Male; Middle Aged; Neuroinflammatory Diseases; Plasma Cells; Retrospective Studies

Authors from the University of Münster

Groß, Catharina
Department for Neurology
Pawlowski, Matthias
Department for Neurology
Schulte-Mecklenbeck, Andreas
Department for Neurology
Wiendl, Heinz Siegfried
Department for Neurology