Complement activation contributes to GAD antibody-associated encephalitis.

Chuquisana O, Strippel C, Tröscher AM, Baumgartner T, Rácz A, Keller CW, Elger CE, Melzer N, Kovac S, Wiendl H, Bauer J, Lünemann JD

Abstract

Our data indicate that, in addition to cell-mediated immunity, complement deposition contributes to the pathology of GAD Ab-associated AE. The size of cohorts and the number of patients diagnosed with NSAb-AE entities, due to the rarity of AE, are a limitation of our report and requires validation and mechanistic analyses in larger cohorts