The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transition.
M. Dellin, I. Rohrbeck, P. Asrani, J. A. Schreiber, N. Ritter, F. Glorius, B. Wünsch, T. Budde, L. Temme, T. Strünker, B. Stallmeyer, F. Tüttelmann, S. G. Meuth, M. Spehr, J. Matschke, A. Steinbicker, R. Stoll, N. Strutz-Seebohm, G. Seebohm
Research article (journal) | Peer reviewedDetails about the publication
Journal: Biological Chemistry
Volume: 404
Issue: 4
Page range: 241-254
Status: Published
Release year: 2023
Language in which the publication is written: English
Keywords: binding site; S0 helix; KCNQ1; PIP2; PI1;
Authors from the University of Münster
| Wünsch, Bernhard | Professur für Pharmazeutische Chemie (Prof. Wünsch) |