CILIORETINAL ARTERIES INFLUENCE OPTIC NERVE HEAD, PERIPAPILLARY, AND MACULAR VESSEL DENSITIES IN HEALTHY EYES: An Optical Coherence Tomography Angiography Study

Diener R, Leclaire MD, Eckardt F, Lauermann JL, Alnawaiseh M, Eter N, Treder M

Abstract

BACKGROUND/PURPOSE To analyze the influence of a cilioretinal artery (CRA) on macular and peripapillary vessel density in healthy eyes as measured using optical coherence tomography angiography. METHODS A total of 83 eyes of 83 patients were included in this study. Optical coherence tomography angiography was performed using the RTVue XR Avanti with AngioVue (Optovue Inc). The macula was imaged with a 3 $\times$ 3-mm scan, whereas for the optic nerve head a 4.5 $\times$ 4.5-mm scan was taken. Optical coherence tomography angiography images of the optic nerve head were screened for the presence of a CRA. RESULTS In 31 eyes, a CRA was detected (37.3{\%}). The vessel density in eyes with a CRA was significantly lower within the optic nerve head (P = 0.005) but higher in the peripapillary capillary network (P {\textless} 0.001) and (whole en face) macular superficial capillary plexus (P = 0.025), when compared with eyes with no CRA. CONCLUSION Our findings reveal that in eyes with a CRA, the vessel density in the peripapillary and macular superficial capillary plexus is increased, whereas the optic nerve head perfusion (as indicated by vessel density in the inside disk region) is decreased. This has to be considered when analyzing quantitative optical coherence tomography angiography parameters in scientific and clinical applications.