An Achilles' Heel for MLL-Rearranged Leukemias: Writers and Readers of H3 Lysine 36 Dimethylation
Balbach ST, Orkin SH
Research article (journal) | Peer reviewedAbstract
Histone H3 lysine 36 dimethylation (H3K36me2), a modification associated with transcriptional activation, is required for mixed-lineage leukemia-dependent transcription and leukemic transformation. In this issue of Cancer Discovery, Zhu and colleagues map the network of readers, writers, and erasers of H3K36me2 and uncover the ASH1L histone methyltransferase as a novel target for therapeutic intervention. Cancer Discov; 6(7); 700-2. {çopyright}2016 AACR.See related article by Zhu and colleagues, p. 770.
Details about the publication
Volume: 6
Issue: 7
Page range: 700-702
Status: Published
Release year: 2016
Language in which the publication is written: English
Authors from the University of Münster
| Balbach, Sebastian | University Children's Hospital - Department of Paediatric Haematology and Oncology (UKM PHO) |