DNA Films Containing the Artificial Nucleobase Imidazole Mediate Charge Transfer in a Silver(I)-Responsive Way
Léon JC, She Z, Kamal A, Shamsi M, Müller J, Kraatz H-B
Research article (journal) | Peer reviewedAbstract
The first sequence-dependent study of DNA films containing metal-mediated base pairs was performed to investigate the charge transfer resistance (RCT) of metal-modified DNA. The imidazole (Im) deoxyribonucleoside was chosen as a highly AgI-specific ligandoside for the formation of Im–AgI–Im complexes within the duplexes. This new class of site-specifically metal-modified DNA films was characterized by UV, circular dichroism (CD), and X-ray photoelectron spectroscopy (XPS). The electrochemical properties of these systems were investigated by means of electron impedance spectroscopy and scanning electrochemical microscopy. Taken together, these experiments indicated that the incorporation of AgI ions into the DNA films leads to reduced electron transfer through the DNA films. A simple device was proposed that can be switched reversibly between two distinct states with different charge transfer resistance.
Details about the publication
Authors from the University of Münster
| Léon, Jens Christian | Professorship of Inorganic Chemistry (Prof. Hahn) |
| Müller, Jens | Professorship of Inorganic Chemistry (Prof. Müller) |
Projects the publication originates from
Duration: 01/07/2014 - 31/12/2018 | 1st Funding period Funded by: DFG - International Research Training Group Type of project: Main DFG-project hosted at University of Münster |
Promotionen, aus denen die Publikation resultiert
| Development of site-specifically silver(I)-modified DNA and its applications in nano-, surface- and electrochemistry Candidate: Léon, Jens Christian | Supervisors: Müller, Jens Period of time: 02/03/2015 - 30/05/2018 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster |