MiR-142-3p is a novel regulator of cell viability and proinflammatory signalling in endometrial stroma cells
Kästingschäfer C., Schäfer S., Kiesel L., Götte M.
Research article (journal) | Peer reviewedAbstract
Endometriosis is associated with severe pelvic pain and reduced fertility. Recently, it has been linked to a dysregulation of microRNAs (miRNAs), which are post-transcriptional regulators of gene expression. The functional effect of dysregulated miR-142-3p expression in endometrial stroma cells was investigated. An increased expression of miR-142-3p resulted in a significantly reduced expression of steroid sulfatase and interleukin-6-coreceptor gp130 as well as reduced interleukin-6-mediated activation of the STAT3-pathway, suggesting an effect of miR-142-3p both on steroid hormone- and cytokine-mediated signalling events. At the functional level, miR-142-3p overexpression significantly reduced cell viability (P ≤ 0.01). miR-142-3p regulation emerges as a future therapeutic strategy for endometriosis.
Details about the publication
Authors from the University of Münster
| Götte, Martin | Department of Gynecology and Obstetrics |
| Kiesel, Ludwig | Department of Gynecology and Obstetrics |
| Schäfer, Sebastian Daniel | Department of Gynecology and Obstetrics |
Preisverleihungen erhalten für die Publikation
| DVR-Posterpreis Awarded by: Dachverband für Reproduktionsbiologie und -medizin (DVR) Award given to: Kästingschäfer, Christin; Götte, Martin Date of awarding: 01/01/2014 Type of distinction: Best publication award |
Promotionen, aus denen die Publikation resultiert
| Einfluss der mikroRNA miR-142-3p auf Zellviabilität, Migrationsfähigkeit und proinflammatorische Signaltransduktionsvorgänge in endometrialen Stromazellen Candidate: Kästingschäfer, Christin Susanna | Supervisors: Götte, Martin; Greve, Burkhard Period of time: until 01/03/2015 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster |