Epigenetic control of hematopoiesis: The PU.1 chromatin connection

Van Riel B., Rosenbauer F.

Review (journal) | Peer reviewed

Abstract

Purine-rich box1 (PU.1) is a transcription factor that not only has a key role in the development of most hematopoietic cell lineages but also in the suppression of leukemia. To exert these functions, PU.1 can cross-talk with multiple different proteins by forming complexes in order to activate or repress transcription. Among its protein partners are chromatin remodelers, DNA methyltransferases, and a number of other transcription factors with important roles in hematopoiesis. While a great deal of knowledge has been acquired about PU.1 function over the years, it was the development of novel genome-wide technologies, which boosted our understanding of how PU.1 acts on the chromatin to drive its repertoire of target genes. This review summarizes current knowledge and ideas of molecular mechanisms by which PU.1 controls hematopoiesis and suppresses leukemia.

Details about the publication

Volume395
Issue11
Page range1265-1274
StatusPublished
Release year2014
Language in which the publication is writtenEnglish
DOI10.1515/hsz-2014-0195
Link to the full texthttp://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84907661989&origin=inward
KeywordsChromatin; epigenetics; hematopoiesis; PU.1

Authors from the University of Münster

Rosenbauer, Frank
Institute of Molecualr Tumor Biology
van Riel, Boet
Institute of Molecualr Tumor Biology