Unexpected Beneficial Effect of ortho-Substituents on the (S)-Proline-Catalyzed Asymmetric Aldol Reaction of Acetone with Aromatic Aldehydes
Martínez A., van Gemmeren M., List B.
Research article (journal) | Peer reviewedAbstract
An intriguing effect of electronegative 2,6-substituents on the stereochemical outcome of (S)-proline-catalyzed aldol reactions between benzaldehyde derivatives and acetone is reported. Remarkably high enantioselectivities can be achieved with such substrates. © Georg Thieme Verlag Stuttgart New York.
Details about the publication
Journal: SYNLETT
Volume: 25
Issue: 7
Page range: 961-964
Status: Published
Release year: 2014
Language in which the publication is written: English
Link to the full text: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84898538484&origin=inward
Keywords: aldehyde; aldol reaction; asymmetric catalysis; organocatalysis; proline
Authors from the University of Münster
| van Gemmeren, Manuel | Professur für Organische Chemie (Prof. Glorius) |