The recombinant bacteriophage endolysin HY-133 exhibits in vitro activity against different African clonal lineages of the staphylococcus aureus complex, including staphylococcus schweitzeri

Idelevich E., Schaumburg F., Knaack D., Scherzinger A., Mutter W., Peters G., Peschel A., Becker K.

Abstract

HY-133 is a recombinant bacteriophage endolysin with bactericidal activity against Staphylococcus aureus. Here, HY-133 showed in vitro activity against major African methicillin-susceptible and methicillin-resistant S. aureus lineages and ceftaroline/ceftobiprole-and borderline oxacillin-resistant isolates. HY-133 was also active against Staphylococcus schweitzeri, a recently described species of the S. aureus complex. The activity of HY-133 on the tested isolates (MIC50, 0.25 μg/ml; MIC90, 0.5 μg/ml; range, 0.125 to 0.5 μg/ml) was independent of the species and strain background or antibiotic resistance.