Drug-eluting balloons for femoropopliteal lesions show better performance in de novo stenosis or occlusion than in restenosis

Herten M., Torsello G., Schönefeld E., Imm B., Osada N., Stahlhoff S.

Research article (journal) | Peer reviewed

Abstract

Objective Although drug-eluting balloons (DEBs) have shown promising results treating de novo (DN) atherosclerotic lesions and appear to have been widely adopted in Europe, their long-term efficacy in the broad spectrum of femoropopliteal restenosis (RE) remains to be proven. The purpose of the study was to assess the efficacy of paclitaxel-DEBs in restenotic (stented and nonstented) vs DN stenotic femoropopliteal arteries. Methods The study prospectively enrolled 100 patients undergoing femoropopliteal endovascular intervention by DEB for RE or DN stenosis. Patients who received additive atherectomy were excluded. The primary end point was the primary patency (PP) rate at 12 months. Secondary end points were sustained clinical improvement and clinically driven target lesion revascularization. Results DEBs were used to treat 105 limbs for intermittent claudication (82 [78%]) or critical limb ischemia (23 [22%]) in 100 patients. Of these, 111 lesions were DN stenosis (46 [41%]) or RE (65 [59%]). The overall PP was 86% at 6 months and 74% at 12 months. PP of DN stenosis was higher at 6 months (93% vs 81%) and was significantly (P =.021) better than RE at 12 months (85% vs 68%). Sustained clinical improvement based on Rutherford classification was significant in both groups (P

Details about the publication

JournalJournal of Vascular Surgery (J Vasc Surg)
Volume61
Issue2
Page range394-399
StatusPublished
Release year2015
Language in which the publication is writtenEnglish
DOI10.1016/j.jvs.2014.08.005
Link to the full texthttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84921464154&origin=inward

Authors from the University of Münster

Herten, Monika
Clinic for vascular and endovascular Surgery
Schönefeld, Eva
Institute of Medical Training and Academic Affairs
Torsello, Giovanni
Clinic for vascular and endovascular Surgery