Specific loss of cellular L-selectin on CD4+ T cells is associated with progressive multifocal leukoencephalopathy development during HIV infection

Schneider-Hohendorf T., Philipp K., Husstedt I.W., Wiendl H., Schwab N.

Abstract

HIV+ progressive multifocal leukoencephalopathy (PML) patients had a significantly lower expression of CD62L on CD4+ T cells (P<0.001) when compared with HIV+ patients who did not develop PML. CD62L expression on CD4+ T cells did not correlate with parameters such as CDC stage, CD4+ cell percentage (of total CD3 + T cells), CD4+ cell counts, virus count, or clinical parameters. Measurement of CD62L might provide a biomarker for PML risk and could prompt a treatment change and/or close monitoring. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.