Second generation silver(I)-mediated imidazole base pairs
Hensel S, Megger N, Schweizer K, Müller J
Research article (journal) | Peer reviewedAbstract
© 2014 Hensel et al; licensee Beilstein-Institut. The imidazole-Ag(I)-imidazole base pair is one of the best-investigated artificial metal-mediated base pairs. We show here that its stability can be further improved by formally replacing the imidazole moiety by a 2-methylimidazole or 4-methylimidazole moiety. A comparison of the thermal stability of several double helices shows that the addition of one equivalent of Ag(I) leads to a 50% larger increase in the melting temperature when a DNA duplex with methylated imidazole nucleosides is applied. This significant effect can likely be attributed to a better steric shielding of the metal ion within the metal-mediated base pair.
Details about the publication
Journal: Beilstein Journal of Organic Chemistry
Volume: 10
Page range: 2144null
Status: Published
Release year: 2014 (09/09/2014)
Language in which the publication is written: English
DOI: 10.3762/bjoc.10.221
Authors from the University of Münster
| Megger, Nicole | Institute of Inorganic and Analytical Chemistry |
| Müller, Jens | Professorship of Inorganic Chemistry (Prof. Müller) |
Projects the publication originates from
Duration: 01/01/2010 - 31/12/2017 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |