A catalytic asymmetric Fujiwara-Moritani cyclization

Schiffner JA, Machotta AB, Oestreich M

Abstract

An enantioselective intramolecular Fujiwara-Moritani reaction involving direct C-H functionalization using modified PyOX ligands is reported for the first time. Screening of several ligand-oxidant combinations eventually produced a stereogenic quaternary carbon with promising enantiocontrol (54% ee) and in good chemical yield (71%).