Late-Onset Hypoparathyroidism-Induced Hypocalcemia in a Very Low Birth Weight Infant Caused by Undiagnosed Maternal Hyperparathyroidism.

Beyer A; Franssen M; Böckenholt K; Rohde J; Domning E; Schneider F

Abstract

OBJECTIVE - STUDY DESIGN - RESULTS - CONCLUSION; To describe a rare case of late-onset neonatal hypocalcemia in a very preterm infant caused by maternal adenoma-related hyperparathyroidism (HyperPT) and to discuss diagnostic and therapeutic implications.; Case report of a preterm infant born at 29 weeks of gestation with very low birth weight. Clinical course, laboratory findings, maternal history, and management were reviewed to identify the etiology and guide treatment.; The infant developed transient, asymptomatic hypocalcemia during the neonatal period. Maternal evaluation revealed primary HyperPT due to a parathyroid adenoma as the underlying cause. The newborn responded to calcium supplementation and optimized vitamin D therapy.; Maternal HyperPT can cause delayed neonatal hypocalcemia even in preterm infants. Early recognition through coordinated maternal-neonatal evaluation is crucial. Optimal vitamin D administration and close interdisciplinary communication between obstetrics and neonatology are essential for prevention and management.