Concomitant Ewing sarcoma and acute lymphoblastic leukemia in a 5-year-old girl
Masjosthusmann K, Bielack SS, Kohler G, Florax A, Schiborr M, Bruch J, Reinhardt D, Kuhn N, Paulussen M, Jurgens H
Research article (journal)Abstract
Malignancies from the Ewing family of tumors and acute lymphoblastic leukemia (ALL) are not known to be associated with each other. A 5-year-old girl was incidentally found to suffer from acute lymphoblastic leukemia during bone marrow staging for Ewing sarcoma of the radius. The simultaneous presence of two distinct neoplasms was confirmed by RT-PCR, with EWS/FLI1 type 1 rearrangement in the bone tumor and TEL/AML1 rearrangement in the marrow. She was treated with chemotherapy, radiotherapy, and surgery and was in remission of both diseases 31 months after diagnosis.
Details about the publication
Journal: Pediatric Blood and Cancer
Volume: 45
Issue: 6
Page range: 846-849
Status: Published
Release year: 2005 (30/11/2005)
Language in which the publication is written: English
DOI: 10.1002/pbc.20265
Keywords: acute lymphoblastic leukemia Ewing sarcoma secondary neoplasms translocation round-cell tumors 2nd malignancies secondary chemotherapy expression lymphoma children
Authors from the University of Münster
| Masjosthusmann, Katja | University Children's Hospital - Department for General Paediatrics |