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Heterogeneity of radiation- and TNF-alpha-induced programmed cell death in carcinoma, sarcoma and lymphoma cell lines.

Bölling T, Kolkmeyer A, Greve B, Ernst I, Willich N, Könemann S

Research article (journal)

Abstract

To characterize the interaction of tumour necrosis factor alpha (TNF-alpha) and ionising radiation in six sarcoma, lymphoma and carcinoma cell lines.Cells were characterized regarding annexin V/propiduim iodine affinity and caspase-3 status after application of TNF-alpha, radiation, or combined treatment.Three cell lines showed similar results with additive effects of TNF-alpha and radiation in both assays. The other three cell lines significantly differed regarding the detection of apoptotic cells between treatment conditions (radiation and/or TNF application) and between the two apoptosis assays.The interaction between TNF-alpha and radiation differs between tumour entities and cannot be described by using only one parameter.

Details about the publication

Journal: Anticancer Research (Anticancer Res)
Volume: 30
Issue: 7
Page range: 2857-2861
Status: Published
Release year: 2010
Language in which the publication is written: English
Keywords: Humans; Carcinoma; Lymphoma; Tumor Necrosis Factor-alpha; Apoptosis; Sarcoma; Annexin A5. Caspase 3. Cell Line Tumor; Humans; Carcinoma; Lymphoma; Tumor Necrosis Factor-alpha; Apoptosis; Sarcoma; Annexin A5. Caspase 3. Cell Line Tumor

Authors from the University of Münster

Bölling, Tobias
Clinic for Radiotherapy
Ernst, Iris
Clinic for Radiotherapy
Greve, Burkhard
Clinic for Radiotherapy
Willich, Normann
Clinic for Radiotherapy