Heparanase, hyaluronan, and CD44 in cancers: A breast carcinoma perspective
Gotte M, Yip GW
Other scientific publicationAbstract
Glycosaminoglycans are major constituents of the cancer cell surface and the tumor stroma. The heparan sulfate degrading enzyme heparanase, hyaluronan, and its receptor CD44 are up-regulated in breast cancer, generating a microenvironment that promotes tumor progression and metastasis. Recent experimental and clinical evidence shows that heparanase, hyaluronan, and CD44 regulate cancer cell proliferation, migration, and invasion, as well as tumor-associated angiogenesis and are correlated with patient survival. These findings suggest that they may be used as prognostic factors and targets for breast cancer treatment.
Details about the publication
Status: Published
Release year: 2006 (01/11/2006)
Language in which the publication is written: English
Keywords: growth-factor transcription factors mammalian heparanase tumor progression gene-expression metastasis cells angiogenesis resistance inhibition
Authors from the University of Münster
| Götte, Martin |
Projects the publication originates from
Duration: 01/01/2010 - 31/12/2012 Funded by: German-Israeli Foundation for Scientific Research and Development Type of project: Individual project |