Enantioselective Haloetherification by Asymmetric Opening of meso-Halonium Ions.
Hennecke U, Müller CH, Fröhlich R
Research article (journal)Abstract
A new approach to enantioselective haloetherification reactions via desymmetrization of in situ-generated meso-halonium ions is described. The combination of N-haloamides as a halogen source and sodium salts of chiral phosphoric acids as catalysts can be used for the cyclization of symmetrical ene-diol substrates, yielding the haloetherification products under practical conditions in enantioenriched form.
Details about the publication
Journal: Organic letters (Org Lett)
Volume: 13
Issue: 5
Page range: 860-863
Status: Published
Release year: 2011 (04/03/2011)
DOI: 10.1021/ol1028805
Authors from the University of Münster
| Fröhlich, Roland | Organic Chemistry Institute |
| Hennecke, Ulrich | Professur für Organische Chemie (Prof. Studer) |