Characterization of endometrial mesenchymal stem-like cells obtained by endometrial biopsy during routine diagnostics.

Schüring AN, Schulte N, Kelsch R, Röpke A, Kiesel L, Götte M

Abstract

Endometrial cell clones derived from in vitro cultured purified stromal cells obtained by endometrial biopsy display characteristic stem cell features, including clonality; long-term culturing properties; multilineage differentiation potential; expression of CD146, CD105, CD90, CD73, MSI1, NOTCH1, and SOX2; and absence of CD34 and CD14 expression. We conclude that adult stem cells are present in endometrial biopsies performed in a routine clinical setting, offering new large-scale approaches for future research, diagnostics, and therapies involving adult stem cells.