Synthesis of Saturated N-Heterocycles via a Catalytic Hydrogenation Cascade

Wagener, Tobias; Pierau, Marco; Heusler, Arne; Glorius, Frank

Abstract

Saturated N-heterocycles are prominent motifs found in various natural products and pharmaceuticals. Despite the increasing interest in this class of compounds, the synthesis of saturated bicyclic azacycles requires tedious multi-step syntheses. Herein, we present a one-pot protocol for the synthesis of octahydroindoles, decahydroquinolines, and octahydroindolizines through a cascade reaction.