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Lewis acid-catalyzed [2π+2σ] cycloaddition of dihydropyridines with bicyclobutanes

Liang, Yujie; Nematswerani, Ronewa; Daniliuc, Constantin G.; Glorius, Frank

Research article (journal) | Peer reviewed

Abstract

Herein we report a simple BF3-catalyzed cycloaddition of dihydropyridines with bicyclobutanes for the expedient synthesis of novel three-dimensional azacycle-fused bicyclo[2.1.1]hexane scaffolds. The reaction utilizes easily accessible starting materials and proceeds under mild, metal-free conditions with high atom efficiency.

Details about the publication

Journal: Chemical communications (Chem. Commun.)
Volume: 61
Issue: 10
Page range: 2091-2094
Status: Published
Release year: 2025
DOI: 10.1039/d4cc06133k
Link to the full text: https://pubs.rsc.org/en/content/articlelanding/2025/cc/d4cc06133k
Keywords: Cycloadditions; Atom Efficiency; Catlysis

Authors from the University of Münster

Daniliuc, Constantin-Gabriel
Organic Chemistry Institute
Glorius, Frank
Professur für Organische Chemie (Prof. Glorius)