Collagen XVI expression is upregulated in glioblastomas and promotes tumor cell adhesion.
Senner V, Ratzinger S, Mertsch S, Grässel S, Paulus W
Research article (journal)Abstract
The poor prognosis of glioblastoma patients is related to diffuse brain invasion and interaction of tumor cells with extracellular matrices (ECM). We describe expression and function of the FACIT-collagen XVI in glioblastomas. We found upregulation of collagen XVI mRNA as well as protein in glioblastomas as compared to normal cortex. SiRNA knockdown resulted in decreased cell adhesion whereas increased adhesion was observed on surfaces coated with collagen XVI. The migration of glioblastoma cells on this substrate remained unchanged. Our results demonstrate de-novo expression of collagen XVI in glioblastomas as part of the tumor specific remodeling of the ECM.
Details about the publication
Journal: FEBS Letters
Volume: 582
Issue: 23-24
Page range: 3293-300
Status: Published
Release year: 2008
Language in which the publication is written: English
Keywords: Fibril-Associated Collagens; Cell Movement; Glioblastoma; Up-Regulation; Cell Line Tumor; Humans; Cell Adhesion; Collagen; Extracellular Matrix; Fibril-Associated Collagens; Cell Movement; Glioblastoma; Up-Regulation; Cell Line Tumor; Humans; Cell Adhesion; Collagen; Extracellular Matrix
Authors from the University of Münster
| Mertsch, Sonja | Institute of Neuropathology |
| Paulus, Werner | Institute of Neuropathology |
| Senner, Volker | Institute of Neuropathology |