[Leg ulcer in mixed connective tissue disease. Resolution during sitaxsentan therapy]
Becker H, Sunderkoetter C, Willeke P, Domschke W, Gaubitz M, Mohr M
Research article (journal)Abstract
Leg ulcers may result in serious morbidity in patients with connective tissue diseases and Raynaud's phenomenon (RP). We describe a 35-year-old woman with mixed connective tissue disease who suffered from leg ulcers refractory to iloprost. When the patient was treated with the selective endothelin A receptor antagonist sitaxsentan for pulmonary arterial hypertension, the ulcers improved within 4 weeks and resolved completely thereafter. In addition, severity of RP ameliorated markedly. Further evaluation of sitaxsentan in patients with connective tissue diseases suffering from ischemic skin ulcers is required.
Details about the publication
Journal: Zeitschrift für Rheumatologie (Z Rheumatol)
Volume: 68
Issue: 2
Page range: 154-156
Status: Published
Release year: 2009
Language in which the publication is written: German
Keywords: Leg Ulcer; Female; Raynaud Disease; Thiophenes; Antihypertensive Agents; Scleroderma Systemic; Adult; Humans; Treatment Outcome; Isoxazoles; Leg Ulcer; Female; Raynaud Disease; Thiophenes; Antihypertensive Agents; Scleroderma Systemic; Adult; Humans; Treatment Outcome; Isoxazoles
Authors from the University of Münster
| Becker, Heidemarie | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
| Willeke, Peter | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |