The regulation of immune cell trafficking by the extracellular matrix

Hallmann R., Zhang X., Di Russo J., Li L., Song J., Hannocks M., Sorokin L.

Review (journal) | Peer reviewed

Abstract

The extracellular matrix (ECM) comes in different structural forms and biochemical compositions, which determine both its biophysical properties and its ability to convey specific signals to immune cells encountering or navigating through it. Traditionally, the role of the individual ECM molecules on cell migration has been investigated independent of considerations such as the tension/mechanical strength constituted by the ECM. However, more recently, this aspect has attracted considerable attention and data suggest that rigidity and molecular signals derived from the ECM define the mode of cell migration. We here review the different types of ECM encountered by migrating immune cells in vivo, as well as current information on how both molecular components of the ECM and their supramolecular structure can impact on modes of immune cell migration.

Details about the publication

Volume36
Issuenull
Page range54-61
StatusPublished
Release year2015
Language in which the publication is writtenEnglish
DOI10.1016/j.ceb.2015.06.006
Link to the full texthttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84937124634&origin=inward

Authors from the University of Münster

Di Russo, Jacopo
Institute of Physiological Chemistry and Pathobiochemistry
Hallmann, Rupert
Institute of Physiological Chemistry and Pathobiochemistry
Hannocks, Melanie-Jane
Institute of Physiological Chemistry and Pathobiochemistry
Song, Jian
Institute of Physiological Chemistry and Pathobiochemistry
Sorokin, Lydia
Institute of Physiological Chemistry and Pathobiochemistry
Zhang, Xueli
Institute of Physiological Chemistry and Pathobiochemistry