STIM2: Redox-sensor and effector of the (tumor) microenvironment

Schwab, Albrecht; Loeck, Thorsten; Najder-Nalepa, Karolina

Abstract

Ion channels and their associated proteins are at the interface between the cytosol and the extracellular space. In cancer, this allows them to sense and transduce physico-chemical cues from the tumor microenvironment and thereby shape the aggressive cell behavior. In a recent paper Gibhardt et al. provide profound mechanistic insight how STIM2, an integral component of the store-operated Ca2+ entry (SOCE) mechanism in melanoma cells, is redox-regulated.