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STIM2: Redox-sensor and effector of the (tumor) microenvironment

Schwab, Albrecht; Loeck, Thorsten; Najder-Nalepa, Karolina

Research article (journal) | Peer reviewed

Abstract

Ion channels and their associated proteins are at the interface between the cytosol and the extracellular space. In cancer, this allows them to sense and transduce physico-chemical cues from the tumor microenvironment and thereby shape the aggressive cell behavior. In a recent paper Gibhardt et al. provide profound mechanistic insight how STIM2, an integral component of the store-operated Ca2+ entry (SOCE) mechanism in melanoma cells, is redox-regulated.

Details about the publication

Journal: Cell Calcium
Volume: 94
Article number: 102335
Status: Published
Release year: 2021
Language in which the publication is written: English
DOI: 10.1016/j.ceca.2020.102335
Keywords: Redox regulation; STIM2; Store-operated Ca2+ entry (SOCE); Tumor microenvironment

Authors from the University of Münster

Loeck, Thorsten Julian
Institute of Physiology II
Najder-Nalepa, Karolina Maria
Institute of Physiology II
Schwab, Albrecht
Institute of Physiology II

Projects the publication originates from

RTG 2515: Chemical Biology of Ion Channels (Chembion)
Duration: 01/10/2019 - 31/03/2024 | 1st Funding period
Funded by: DFG - Research Training Group
Type of project: Main DFG-project hosted at University of Münster