Decreased spermatogonial numbers in boys with severe haematological diseases.

Lahtinen AK; Funke M; Krallmann C; Wyrwoll MJ; Jarisch A; Yang Y; Bjarnason R; Romerius P; Sundin M; Norén-Nyström U; Langenskiöld C; Cremers JF; Kliesch S; Stukenborg JB; Neuhaus N; Jahnukainen K

Abstract

This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi anaemia exhibit significantly reduced spermatogonial numbers. Patients with immunodeficiency or aplastic anaemia generally present within the normal range, while results in patients with myelodysplastic syndrome or myeloproliferative neoplasm vary. The study emphasizes the importance of assessing spermatogonial numbers in patients with severe haematological diseases for informed fertility preservation decisions.