Scanning Probe Microscopy techniques for real time, high resolution imaging and molecular recognition in functional and structural genomics (TIPS4CELLS)

Basic data for this project

Type of projectEU-project hosted outside University of Münster
Duration at the University of Münster01/02/2005 - 31/07/2008

Description

High resolution imaging of living cells and subcellular components is essential for functional and structural genomics'. Scanning Probe Microscopy (SPM) has evolved into the imaging method of choice that yields the greatest structural details on biological samples such as proteins, nucleotides, membranes and cells in their native, aqueous environment and at ambient conditions. In addition, due to its high lateral resolution and sensitive force detection capability, the exciting possibility of measuring inter- and intra-molecular forces of bio-molecules on the single molecule level has become possible, leading to new possibilities for the evolution of methods that will enable us to examine the physiological consequences of, even, the interaction of a single ligand molecule with its cognate receptor.In this project we propose to develop Scanning Probe Microscopy to advance the state of the art of this technique. With the support of the Sixth Framework program, Scanning Probe Microscopy is ready to become a mature imaging and measurement platform for cell biology that will become as widespread in the biomedicai laboratory as the confocal microscope, adding value to the European scientific instrument market and giving it a major presence worldwide.

KeywordsScanning Probe Microscopy; SPM; Scanning Force Microscopy
Funding identifier512101
Funder / funding scheme
  • EC FP 6 - Networks of Excellence (NoE)

Project management at the University of Münster

Oberleithner, Hans
Institute of Physiology II

Applicants from the University of Münster

Oberleithner, Hans
Institute of Physiology II

Project partners outside the University of Münster

  • Scientec (SCIENTEC)France
  • Jpk Instruments Ag (JPK INSTRUMENTS AG)Germany
  • Leiden Probe Microscopy (LPM)Netherlands (Kingdom of the)
  • Weizmann Institute of ScienceIsrael
  • Johannes Kepler Universität Linz (JKU)Austria
  • University of Bristol (UNIVBRIS)United Kingdom
  • Leiden University (UL)Netherlands (Kingdom of the)

Coordinating organisations outside the University of Münster

  • Leiden University (UL)Netherlands (Kingdom of the)