CTC TRR 61 C07 - Artificial nucleic acids with metal-based luminescent properties
Basic data for this project
Description
The utilization of artificial metal-mediated base pairs represents an elegant and innovative tool for the site-specific introduction of metal-based functionality into the world of nucleic acids. In an effort to enable applications of nanoscale self-assembling luminescent constructs in DNA-based nanotechnology, this project will focus on the development and characterization of nucleic acids comprising photoactive metal-mediated base pairs.The base pairs will be designed in a way that the optical properties derive mainly from metallophilic interac-tions between two vicinal metal ions, rather than from the respective artificial nucleobases. Thus, two metal ions within the same or between neighbouring metal-mediated base pairs will be introduced. In addition, novel artificial bases will be developed with increased affinity towards metal ions whose complexes and clusters display well-known photophysical properties, such as Au(I), Au(III) or Pt(II). The structural constraints imposed by the double helices and the metallophilic interactions are expected to give rise to previously unexplored spectroscopic properties, thus opening an entirely new field of basic research.
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Müller, Jens | |
| Strassert, Cristian |
Applicants from the University of Münster
| Müller, Jens | |
| Strassert, Cristian |
Research associates from the University of Münster
| Litau, Stefanie | |
| Richters, Tim | |
| Stegemann, Linda |
Related main project
CRC TRR 61 - Multilevel Molecular Assemblies: Structure, Dynamics and Function (2nd funding period) (SFB TRR 61) Duration: 01/07/2012 - 30/06/2017 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |
Publications of the University of Münster resulting from the project
Tan X, Litau S, Zhang X, Müller J (2015) In: Langmuir, 31, 11305-11310. doi:10.1021/acs.langmuir.5b03183 Research article (journal) | Peer reviewed | Published | |
Litau S, Müller J (2015) In: ZAAC - Zeitschrift für Anorganische und Allgemeine Chemie / Journal of Inorganic and General Chemistry, 641, 2169-2173. doi:10.1002/zaac.201500534 Research article (journal) | Peer reviewed | Published | |
Litau S, Müller J (2015) In: Journal of Inorganic Biochemistry, 148, 116-120. doi:10.1016/j.jinorgbio.2015.01.004 Research article (journal) | Peer reviewed | Published |
Doctorates resulting from the project
| Triazol-basierte tridentate Liganden und ihre Platin(II)-Komplexe: Synthese, Lumineszenz und Interaktion mit DNA Candidate: Hebenbrock, Marian | Supervisors: Müller, Jens Period of time: 01/01/2015 - 26/01/2018 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster | |
| Untersuchungen zur Lumineszenz verschiedener metallvermittelter Basenpaare und Einzelmolekül-Kraftspektroskopie an DNA mit einem Imidazol–Ag+–Imidazol-Basenpaar Candidate: Litau, Stefanie | Supervisors: Müller, Jens Period of time: 01/10/2011 - 15/09/2015 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster |