Functional antigen matching in corneal transplantation (FANCY)

Basic data for this project

Type of projectIndividual project
Duration at the University of Münster01/01/2009 - 31/12/2011

Description

This is our continuation application for DFG. We already announced this application for continuation in our original proposal. The summary from our original proposal still holds: Corneal diseases are among the five most common causes of blindness. Keratoplasty can potentially restore vision in most cases. Immunological graft reactions, however, may induce irreversible graft failure in 20-50%. Matching for transplantation antigens is potentially effective for a lifetime without side-effects contrary to the pharmacological approaches. The purpose of the FANCY trial is to demonstrate superiority of HLA matching in comparison to standard care, namely sequential (‘random’) graft assignment.So far, we succeeded in screening the 720 patients we strived for. We owe this success to our highly motivated investigators. These compensated the drop out of two big centres from the start. We additionally managed to overcome the unforeseeable black-out of our monitoring contractor in the midst of the patient recruiting period. We therefore need three additional years to complete the HLA matching and follow up. However, the FANCY trial is still on budget despite the delays. We herein apply for the originally announced funding beyond the first three years. Without this funding, all endeavours so far would be of no avail.

KeywordsAugenheilkunde
DFG-Gepris-IDhttps://gepris.dfg.de/gepris/projekt/73670179
Funding identifierBO 3198/2-1 | DFG project number: 73670179
Funder / funding scheme
  • DFG - Clinical Trial

Project management at the University of Münster

Uhlig, Constantin
Clinic for Ophthalmology

Applicants from the University of Münster

Uhlig, Constantin
Clinic for Ophthalmology

Project partners outside the University of Münster

  • University Medical Center Freiburg (UKF)Germany