CRC 1009 B07 - The role of RANK/RANKL signaling for skin homeostasis and barrier function during anti-microbial immune responses
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 30/06/2020 | 2nd Funding period
Description
In cutaneous Herpes simplex virus infection we have shown that the RANK/RANKL pathway is critically involved in barrier protection and the expansion of virus-specific CD8+ effector T cells. Now we will analyse the role of RANKL signalling on innate anti-microbial immunity, memory responses and long-lasting barrier preservation during skin infections. Moreover, we will assess whether RANK/RANKL interactions represent a general mechanism, which protects from infections and controls barrier integrity in other epithelial tissues than the skin.
Keywords: Skin immunology
Website of the project: https://campus.uni-muenster.de/sfb-1009/projekte/projektbereich-b/b-07/
Funding identifier: SFB 1009/2
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Loser, Karin | Clinic for Dermatology |
Applicants from the University of Münster
| Loser, Karin | Clinic for Dermatology |