CRC 1009 A09 - Interplay of integrin-mediated adhension and MMP14-driven proteolysis in matrix barrier-breaking invadopodia of tumour cells

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/07/2016 - 30/06/2020 | 2nd Funding period

Description

The molecular linkage between b1 integrins and MMP14 within invadopodia of melanoma cells will be disclosed at protein-chemical and cellular level. To study their functional linkage, integrin-dependent localization and activity of MMP14 within invadopodia will be analyzed. Inhibition of melanoma invasion by individually targeting MMP14 will be compared with an approach of dual targeting both b1 integrins and MMP14 with novel bifunctional integrin- and MMP14-targeting (BIMT) molecules at the cellular level. Translationally, BIMTs will be tested for their potential to inhibit melanoma invasion in chicken CAM and murine lung assay.

Keywords: Vascular Matrix Biology; Integrin-Matrix Interaction; Protein Chemistry

Website of the project: https://campus.uni-muenster.de/sfb-1009/projekte/projektbereich-a/a-09/

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/256179552

Funding identifier: SFB 1009/2 | DFG project number: 194468054

Funder / funding scheme:

DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Institute of Physiological Chemistry and Pathobiochemistry

Applicants from the University of Münster

Institute of Physiological Chemistry and Pathobiochemistry

Projects of the previous funding period

SFB 1009 A09 - Der Adhäsomtyp als Determinante für Funktion und Differenzierung von Gefäßzellen

Duration: 01/01/2014 - 30/06/2016 | 1st Funding period

Funded by: DFG - Collaborative Research Centre

Type of project: Subproject in DFG-joint project hosted at University of Münster

Projects of the following funding period

CRC 1009 - A09: Interplay of cell adhesion and matrix proteolysis in barrier-braking invadopodia of tumor cells

Duration: 01/07/2020 - 30/06/2024 | 3rd Funding period

Funded by: DFG - Collaborative Research Centre

Type of project: Subproject in DFG-joint project hosted at University of Münster

Related main project

SFB 1009 - Breaking Barriers - Immune cells and pathogens at cell / matrix barriers (SFB 1009/2)

Duration: 01/07/2016 - 30/06/2020 | 2nd Funding period

Funded by: DFG - Collaborative Research Centre

Type of project: Main DFG-project hosted at University of Münster

Publications of the University of Münster resulting from the project

Rhodocetin-αβ selectively breaks the endothelial barrier of the tumor vasculature in HT1080 fibrosarcoma and A431 epidermoid carcinoma tumor models

Niland, Stephan; Komljenovic, Dorde; Macas, Jadranka; Bracht, Thilo; Bäuerle, Tobias; Liebner, Stefan; Eble, Johannes A (2018)

In: Oncotarget, 9(32), 22406-22422. doi:10.18632/oncotarget.25032

Research article (journal) | Peer reviewed | Published