SFB TRR 58 - C02: Anxiety and emotional perception - Modulation by the adenosine, dopamine and endocannabinoid system

Basic data for this project

Description

The present project aims at an integrative approach to the investigation of the complex interaction between neurobiological factors and emotional perception in the pathogenesis of anxiety in humans using an in vitro model of anxiety pathogenesis to imitate the natural course in the development of pathological anxiety. Particular attention is paid to arousal-increasing neurotransmitter systems such as the adenosine, dopamine and endocannabinoid system on a genetic as well as neurobiological level. The results may aid in improving primary and secondary prevention by sharpening genetic/neurobiological and perceptual risk profiles of anxiety prone individuals and consequently by contributing to individually tailored psycho- and/or pharmacotherapy of anxiety disorders. The effects of modulators of the respective neurotransmitter systems, particularly the CB1 receptor antagonist rimonabant, on anxiety levels in humans and therefore a potential role of derived substances as innovative therapeutic agents in anxiety disorders will be determined.