EXC 1003 FF-2013-03 - Analysis of new actin regulators controlling cell shape, cell dynamics and cell polarity in Drosophila hemocytes
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2013 - 30/06/2016 | 1st Funding period
Description
Drosophila blood cells (hemocytes) are an excellent model system for studying conserved gene functions in actin dynamics driven processes such as directional cell migration, phagocytosis or wound healing in a physiological environment. In order to identify new gene functions required for cell shape and cell migration we started to perform a RNAi screen in Drosophila hemocytes. High-resolution SIM and Spinning-Disc imaging techniques allows a precise phenotypic analysis of gene knockdown ex vivo and in vivo. Computational image analysis will complement this qualitative analysis and allows a classification of cellular morphologies or migration defects.
Keywords: actin regulators; cell shape; cell dynamics; cell polarity; Drosophila
Website of the project: http://www.uni-muenster.de/Cells-in-Motion/research/flexible-fund-projects/FF-2013-03.php
Funder / funding scheme:
- DFG - Cluster of Excellence (EXC)
Project management at the University of Münster
| Bogdan, Sven | Professorship of Neuro- and Behavioral Biology (Prof. Klämbt) |
| Jiang, Xiaoyi | Professur für Praktische Informatik (Prof. Jiang) |
Applicants from the University of Münster
| Jiang, Xiaoyi | Professur für Praktische Informatik (Prof. Jiang) |