EXC 1003 FF-2013-29 - Mathematical Modeling, Molecular Dynamics, and Experiments
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2013 - 30/06/2015 | 1st Funding period
Description
Lipid molecules diffuse 2-dimensionally within the lipid bilayer and can form domains of different lipid compositon (lipid rafts). These lipid rafts are thought to play an important role in signal transduction and membrane trafficking. In this project 1. phase separation in giant unilamellar vesicles will be followed online microscopically in chambers that allow change of ambient conditions. 2. Computer simulations for ternary lipid mixtures will be performed, using a coarse grained modeling procedure. 3. Macroscopic mathematical models for phase separation, forming periodic patterns will be developed and analyzed w.r.t. their underlying possible microscopid features.
Keywords: lipid rafts; signal transduction; membrane trafficking; computer simulations; mathematical models; biological chemistry; mathematics
Website of the project: http://www.uni-muenster.de/Cells-in-Motion/de/research/flexible-fund-projects/FF-2013-29.php
Funder / funding scheme:
- DFG - Cluster of Excellence (EXC)
Project management at the University of Münster
| Gerke, Volker | Institute of Medical Biochemistry |
| Heuer, Andreas | Professorship of Theory of Complex Systems |
| Stevens, Angela | Professur für Angewandte Analysis (Prof. Stevens) |
Applicants from the University of Münster
| Gerke, Volker | Institute of Medical Biochemistry |
| Heuer, Andreas | Professorship of Theory of Complex Systems |
| Stevens, Angela | Professur für Angewandte Analysis (Prof. Stevens) |