pH and Ion Transport in Pancreatic Cancer (pHioniC)
Basic data for this project
Type of project: EU-project hosted at University of Münster
Duration at the University of Münster: 01/11/2018 - 30/06/2023
Description
The molecular mechanisms that give rise to pancreatic cancer remain elusive with hardly any targeted therapies available today. The working hypothesis of the EU-funded pHioniC project is that the pancreas has a unique acidic environment that may facilitate pancreatic cancer initiation and progression. The alkaline pancreatic juice secreted to neutralise the acidic chyme that arrives from the stomach induces temporal changes in pH levels which may drive oncogenic mutations. Researchers will map the pancreatic pH landscape and investigate the mechanism by which it can influence disease progression. Moreover, they will explore potential pH interventions to alter the disease course.
Keywords: pancreatic cancer; physiology; mutation
Website of the project: https://cordis.europa.eu/project/id/813834
Funding identifier: 813834
Funder / funding scheme:
- EC H2020 - Marie Skłodowska-Curie Actions - Innovative Training Network (MSCA ITN)
Project management at the University of Münster
| Schwab, Albrecht | Institute of Physiology II |
Applicants from the University of Münster
| Schwab, Albrecht | Institute of Physiology II |
Management / project coordination at the University of Münster
| Hofschröer, Verena | Institute of Physiology II |
Project partners outside the University of Münster
- Georg-August-Universität GöttingenGermany
- Universita Degli Studi Di Torino (UNITO)Italy
- Universitity of DebrecenHungary
- Universität LilleFrance
- Universita Degli Studi Di Firenze (UNIFI)Italy
- University of Kiel (CAU)Germany
- Erasmus Medical Center Rotterdam (EMC)Netherlands (Kingdom of the)
- University of Copenhagen (UCPH)Denmark
- UNIVERSITY OF BARI ALDO MOROItaly
- University of Picardie Jules VerneFrance
- University of Padua (UNIP)Italy
- University of OxfordUnited Kingdom
- Max Planck Institute for Multidisciplinary Sciences (MPINAT)Germany
- Typeone Biomaterials S.r.l.Italy
- Heidelberg Pharma AGGermany