University of Münster
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pH and Ion Transport in Pancreatic Cancer (pHioniC)

Basic data for this project

Type of project: EU-project hosted at University of Münster
Duration at the University of Münster: 01/11/2018 - 30/06/2023

Description

The molecular mechanisms that give rise to pancreatic cancer remain elusive with hardly any targeted therapies available today. The working hypothesis of the EU-funded pHioniC project is that the pancreas has a unique acidic environment that may facilitate pancreatic cancer initiation and progression. The alkaline pancreatic juice secreted to neutralise the acidic chyme that arrives from the stomach induces temporal changes in pH levels which may drive oncogenic mutations. Researchers will map the pancreatic pH landscape and investigate the mechanism by which it can influence disease progression. Moreover, they will explore potential pH interventions to alter the disease course.

Keywords: pancreatic cancer; physiology; mutation
Website of the project: https://cordis.europa.eu/project/id/813834
Funding identifier: 813834
Funder / funding scheme: 
  • EC H2020 - Marie Skłodowska-Curie Actions - Innovative Training Network (MSCA ITN)

Project management at the University of Münster

Schwab, Albrecht
Institute of Physiology II

Applicants from the University of Münster

Schwab, Albrecht
Institute of Physiology II

Management / project coordination at the University of Münster

Hofschröer, Verena
Institute of Physiology II

Project partners outside the University of Münster

  • University of GöttingenGermany
  • University of Turin (UNITO)Italy
  • Universitity of DebrecenHungary
  • University of Lille (ULille)France
  • University of Florence (UNIFI)Italy
  • Kiel University (CAU)Germany
  • Erasmus Medical Center Rotterdam (EMC)Netherlands (Kingdom of the)
  • University of Copenhagen (UCPH)Denmark
  • University of Bari Aldo MoroItaly
  • University of Picardie Jules VerneFrance
  • University of Padua (UNIP)Italy
  • University of OxfordUnited Kingdom
  • Typeone Biomaterials S.r.l.Italy
  • Heidelberg Pharma AGGermany
  • Max Planck Institute for Multidisciplinary Sciences (MPINAT)Germany

Publications of the University of Münster resulting from the project

Extracellular pH Controls Chemotaxis of Neutrophil Granulocytes by Regulating Leukotriene B4 Production and Cdc42 Signaling
Oster, Leonie; Schröder, Julia; Rugi, Micol; Schimmelpfennig, Sandra; Sargin, Sarah; Schwab, Albrecht; Najder, Karolina (2022)
In: The Journal of Immunology, 209(1), 136-144. doi:10.4049/jimmunol.2100475
Research article (journal) | Peer reviewed | Published
The context-dependent role of the Na+/Ca2+-exchanger (NCX) in pancreatic stellate cell migration
Loeck, Thorsten; Rugi, Micol; Todesca, Luca Matteo; Kalinowska, Paulina; Soret, Benjamin; Neumann, Ilka; Schimmelpfennig, Sandra; Najder, Karolina; Pethő, Zoltán; Farfariello, Valerio; Prevarskaya, Natalia; Schwab, Albrecht (2023)
In: Pflügers Archiv European Journal of Physiology, 475(10), 1225-1240. doi:10.1007/s00424-023-02847-3
Research article (journal) | Peer reviewed | Published