CRC TRR 332 - C05: Phagocytic crosstalk between neutrophils and macrophages in rheumatoid arthritis

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/07/2022 - 30/06/2026 | 1st Funding period

Description

In this proposal, we will decipher the role of coronin 1A (CORO1A) and its interacting partner secretory carrier-associated membrane protein 3 (SCAMP3) for pathogen escape strategies in neutrophils upon infection with Helicobacter pylori and Mycobacterium species. As these pathogens recruit CORO1A to their intracellular niche, we will study how CORO1A and SCAMP3 may be hijacked by these pathogens to circumvent host defence. The identification of these molecular mechanisms may improve our understanding of neutrophil-dependent pathogen escape strategies and can lead to the development of novel therapeutic concepts.

Keywords: Neutrophile; Entzündung; Immunologie; Arthritis; Rheuma

Website of the project: https://www.medizin.uni-muenster.de/sfb-trr-332/forschung/project-area-c.html

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/505403700

Funding identifier: TRR 332/1, C05 | DFG project number: 449437943

Funder / funding scheme: