CRC TRR 332 - C01: The role of the phosphatases CD45 and CD148 in the onset and progression of rheumatoid arthritis

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/07/2022 - 30/06/2026 | 1st Funding period

Description

Rheumatoid arthritis (RA) is an systemic autoimmune disorder characterized by chronic inflammation and synovial infiltration of immune cells. In the arthritic joint, neutrophils are the most abundant population. Phosphatases, and in particular CD45 and CD148, are key molecules in the regulation of neutrophils at the site of inflammation. This study will shed light on how CD45 and CD148 drive leukocyte recruitment during the different phases of arthritis and may hence lay the foundation for a therapeutic approach modulating neutrophil infiltration.

Keywords: Rheuma; Arthritis; Autoimmunerkrankung

Website of the project: https://www.medizin.uni-muenster.de/sfb-trr-332/forschung/project-area-c.html

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/505387492

Funding identifier: TRR 332/1, C01 | DFG project number: 449437943

Funder / funding scheme: