CRC TRR 332 - B03: Neutrophil-intrinsic control of immune activity

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/07/2022 - 30/06/2026 | 1st Funding period

Description

Because neutrophils operate with poor target precision, their activity must be tightly controlled. Recently, we showed that the transcription factor PU.1 shields the chromatin from indiscriminate transcriptional activity, thus safeguarding neutrophils from carrying out an inappropriate immune response. Yet, how neutrophils overcome this PU.1-instructed ‘chromatin barrier’ in infectious situations remains unexplored. Hence, we will here study epigenetic mechanisms operating in neutrophils to fine-tune their activity states during infection and inflammation.

Keywords: Neutrophile; Immunologie

Website of the project: https://www.medizin.uni-muenster.de/sfb-trr-332/forschung/project-area-b.html

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/505386127

Funding identifier: TRR 332/1, B03 | DFG project number: 449437943

Funder / funding scheme: