CRC TRR 332 - B02: Neutrophil modulation during cerebral ischemia by the nuclear receptor NR4A1
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2022 - 30/06/2026 | 1st Funding period
Description
Sterile inflammation upon cerebral ischemia is accompanied by immune cell infiltration. Neutrophils exert a crucial role within the inflammatory response and finally on neuronal damage via interaction with other immune cells of the innate and adaptive immune system. However, unselective blockade of brain neutrophil infiltration has so far been unsuccessful in clinical studies. We hypothesize that neutrophils are differentially modulated in the context of stroke, that the nuclear receptor NR4A1 is critically involved and that pharmacological modulation of NR4A1 opens the possibility of a fine-tuned therapeutic intervention.
Keywords: Ischämie, NR4A1
Website of the project: https://www.medizin.uni-muenster.de/sfb-trr-332/forschung/project-area-b.html
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/505381456
Funding identifier: TRR 332/1, B02 | DFG project number: 449437943
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Klotz, Luisa Hildegard | |
| Minnerup, Jens |
Applicants from the University of Münster
| Klotz, Luisa Hildegard | |
| Minnerup, Jens |
Projects of the following funding period
Duration: 01/07/2026 - 30/06/2030 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Related main project
CRC TRR 332: Neutrophils - origin, fate & function (SFB TRR 332) Duration: 01/07/2022 - 30/06/2026 | 1st Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |