CRC 1348 - A15: Structural insights into the complex interplay between latrotoxin and the cell adhesion receptors neurexin and latrophilin
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2022 - 31/12/2025 | 1st Funding period
Description
The cell adhesion GPCR latrophilin 1 (LPHN1) and neurexins (NRXNs) were discovered as α-latrotoxin (α-LTX) receptors. Both receptors interact with high affinity and presumably form an intercellular adhesion complex. Interaction of the toxin with these receptors induces a conformational change and the insertion of the toxin into the presynaptic membrane, which forms a cation-selective pore that subsequently leads to the degeneration of the synapse. We aim to gain mechanistic insights into the interplay between NRXN, LPHN1 and LTX through structural analyses.
Keywords: Structural Biology; cell adhesion
Website of the project: http://sfb1348.uni-muenster.de/projects/a/project-a15
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/496760974
Funding identifier: SFB 1348/2 A15 | DFG project number: 386797833
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Gatsogiannis, Christos | Institute of Medical Physics and Biophysics Center for Soft Nanoscience (SoN) |
Applicants from the University of Münster
| Gatsogiannis, Christos | Institute of Medical Physics and Biophysics |