CRC 1348 - A08: Molecular parameters for the dynamic assembly of Hedgehog signaling platforms
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2018 - 31/12/2021 | 1st Funding period
Description
This project studies how the sterol-sensing domain (SSD)-containing membrane protein Disp aids Hedgehog (Hh) transport, sorting, or assembly into signaling hubs on the cell surface. We will determine subcellular sites of Disp activity and its possible direct interaction with authentic Hh by using clickable chemical reporters and proximity ligation in conjunction with high-resolution microscopy.
Keywords: subzelluläre Lokalisation; Dispatched; Hedgehog
Website of the project: http://sfb1348.uni-muenster.de/
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/394344789
Funding identifier: SFB 1348/1 A08 | DFG project number: 386797833
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Grobe, Kay |
Applicants from the University of Münster
| Grobe, Kay |
Projects of the following funding period
Duration: 01/01/2022 - 31/12/2025 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Related main project
Duration: 01/01/2018 - 31/12/2021 | 1st Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |