CRC 1348 A08 - Molecular parameters for the dynamic assembly of Hedgehog signaling platforms
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2018 - 31/12/2021 | 1st Funding period
Description
This project studies how the sterol-sensing domain (SSD)-containing membrane protein Disp aids Hedgehog (Hh) transport, sorting, or assembly into signaling hubs on the cell surface. We will determine subcellular sites of Disp activity and its possible direct interaction with authentic Hh by using clickable chemical reporters and proximity ligation in conjunction with high-resolution microscopy.
Keywords: subzelluläre Lokalisation; Dispatched; Hedgehog
Website of the project: http://sfb1348.uni-muenster.de/
Funding identifier: SFB 1348/1 A08
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Grobe, Kay | Institute of Physiological Chemistry and Pathobiochemistry |
Applicants from the University of Münster
| Grobe, Kay | Institute of Physiological Chemistry and Pathobiochemistry |