The project studies receptor-independent signaling platforms, where mechanical forces at the PM are translated into classical biochemical signal transduction cascades via nanoscale membrane deformations. This type of mechano-chemical signal translation at cellular membranes relies on recruitment of curvature-sensitive signaling molecules. Here we aim to investigate how transiently forming curved PM nanodomains regulate actin-based forces in developing mouse neurons.
Galic, Milos | Institute of Medical Physics and Biophysics |
Galic, Milos | Institute of Medical Physics and Biophysics |