CRC TRR 128 - A11: MOG Antibody-Induced CNS Demyelination: from Specificity to Function
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2021 - 30/06/2024 | 1st Funding period
Description
IgG antibodies (Abs) specific for central nervous system (CNS) antigens such as myelin oligodendrocytes glycoprotein (MOG) are considered crucial effector molecules in some patients with multiple sclerosis (MS) and related diseases. In the proposed project, we will characterize structural requirements for immune recognition of human MOG and determine IgG-Fc biophysical profiles and effector functions linked to in vivo pathogenicity of human MOG-Abs.
Keywords: Multiple sclerosis
Website of the project: http://www.sfbtr128.de/a11/
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/447373282
Funding identifier: TRR 128/4, A11 | DFG project number: 213904703
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Lünemann, Jan |
Applicants from the University of Münster
| Lünemann, Jan |
Project partners outside the University of Münster
- University of Munich (LMU)Germany
Related main project
Duration: 01/01/2021 - 30/06/2024 | 3rd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |