CRC TRR 128 A11: MOG Antibody-Induced CNS Demyelination: from Specificity to Function

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/01/2021 - 30/06/2024 | 1st Funding period

Description

IgG antibodies (Abs) specific for central nervous system (CNS) antigens such as myelin oligodendrocytes glycoprotein (MOG) are considered crucial effector molecules in some patients with multiple sclerosis (MS) and related diseases. In the proposed project, we will characterize structural requirements for immune recognition of human MOG and determine IgG-Fc biophysical profiles and effector functions linked to in vivo pathogenicity of human MOG-Abs.

Keywords: Multiple sclerosis

Website of the project: http://www.sfbtr128.de/a11/

Funding identifier: TRR 128/4, A11

Funder / funding scheme:

DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Lünemann, Jan

Department for Neurology

Applicants from the University of Münster