CRC TRR 128 A10: Skin-sensing of environmental factors and their impact on the development of multiple sclerosis

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/01/2021 - 30/06/2024 | 3rd Funding period

Description

In EAE and in a small proof-of-concept study, we characterized immune modulating consequences of UV light and were able to identify the critical relevance of two druggable receptors/transcription factors: melanocortin-1 receptor (MC-1R) and aryl hydrocarbon receptor (AhR) that are responsible for the beneficial effect of UV light. Moreover, we deduced the MC 1R ligand NDP-MSH as an environment mimetic and will now further develop NDP-MSH-containing microparticles towards a potential clinical application as an adjuvant therapeutic. Preclinical studies will be paralleled by investigations in MS patients as well as an exploratory intervention using UV-phototherapy.

Keywords: Multiple sclerosis

Website of the project: http://www.sfbtr128.de/a10/

Funding identifier: TRR 128/4, A10

Funder / funding scheme:

DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Wiendl, Heinz Siegfried

Department for Neurology

Applicants from the University of Münster