CRC TRR 128 A09: Analysis and therapeutic modifications of innate immune regulatory networks in controlling T-cell activation in MS
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2021 - 30/06/2024 | 3rd Funding period
Description
Innate immune-regulatory networks are crucial for controlling T-cell activation in MS. By combining access to unique samples with cutting edge technologies we aim to investigate immune-regulatory networks of peripheral (blood, lymph node) and CNS associated (cerebrospinal fluid) immune compartments to (i) understand alterations of these networks during disease initiation and progression in MS; (ii) identifying parameters discriminating MS from other neuroinflammatory autoimmune diseases; (iii) exploring the impact of immune-modulating therapies on these networks; and (iv) generating an MS-specific immunological roadmap in distinct compartments as a path for diagnostic, prognostic, and therapeutic signatures.
Keywords: Multiple sclerosis
Website of the project: http://www.sfbtr128.de/a09/
Funding identifier: TRR 128/4, A09
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Groß, Catharina | Department for Neurology |
| Wiendl, Heinz Siegfried | Department for Neurology |
Applicants from the University of Münster
| Groß, Catharina | Department for Neurology |
| Wiendl, Heinz Siegfried | Department for Neurology |